In my thinking the question is asking about the problems faced by industries in Pakistan over time. Question is not about the problems caused by industrialization in Pakistan. So one can answer this question in context of industrial development in Pakistan.

A rough outline would be:

1. Power shortage
2. Lack of trained manpower
3. Lack of proper infrastructure
4. Inefficieny
5. Lack of products innovation resulting in concentration of industries in some specific sectors.
6. Changing political and economic policies
7. Bad law and order situation resulting in lower investment in industries
8. Corruption in related government agencies and so many govt. agencies intervention
9. Higher interest rate

These are some of the problems, being faced by industries in Pakistan. One can include more points to the list.

Regards