Saturday, September 26, 2009
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37th Common
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Join Date: Mar 2006
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Mutation
Mutation
Mutation is a change in DNA, the hereditary material of life. An organism’s DNA affects how it looks, how it behaves, and its physiology—all aspects of its life. So a change in an organism’s DNA can cause changes in all aspects of its life.
Mutations are random.
Mutations can be beneficial, neutral, or harmful for the organism, but mutations do not "try" to supply what the organism "needs." In this respect, mutations are random—whether a particular mutation happens or not is unrelated to how useful that mutation would be.
Not all mutations matter to evolution.
Since all cells in our body contain DNA, there are lots of places for mutations to occur; however, not all mutations matter for evolution. Somatic mutations occur in non-reproductive cells and won’t be passed onto offspring.
he only mutations that matter to large-scale evolution are those that can be passed on to offspring. These occur in reproductive cells like eggs and sperm and are called germ line mutations.
A single germ line mutation can have a range of effects:
1. No change occurs in phenotype.
Some mutations don't have any noticeable effect on the phenotype of an organism. This can happen in many situations: perhaps the mutation occurs in a stretch of DNA with no function, or perhaps the mutation occurs in a protein-coding region, but ends up not affecting the amino acid sequence of the protein.
2. Small change occurs in phenotype.
Cat with curled-ear mutation
A single mutation caused this cat’s ears to curl backwards slightly.
3. Big change occurs in phenotype.
Some really important phenotypic changes, like DDT resistance in insects are sometimes caused by single mutations1. A single mutation can also have strong negative effects for the organism. Mutations that cause the death of an organism are called lethals—and it doesn't get more negative than that.
There are some sorts of changes that a single mutation, or even a lot of mutations, could not cause. Neither mutations nor wishful thinking will make pigs have wings; only pop culture could have created Teenage Mutant Ninja Turtles—mutations could not have done it. 
The Causes of Mutations
Mutations happen for several reasons.
1. DNA fails to copy accurately.
Most of the mutations that we think matter to evolution are "naturally-occurring." For example, when a cell divides, it makes a copy of its DNA—and sometimes the copy is not quite perfect. That small difference from the original DNA sequence is a mutation.
2. External influences can create mutations.
Mutations can also be caused by exposure to specific chemicals or radiation. These agents cause the DNA to break down. This is not necessarily unnatural—even in the most isolated and pristine environments, DNA breaks down. Nevertheless, when the cell repairs the DNA, it might not do a perfect job of the repair. So the cell would end up with DNA slightly different than the original DNA and hence, a mutation.
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